Symbol
Name
ID

Il2rg
interleukin 2 receptor, gamma chain
MGI:96551

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes

Reduced natural killer cell activity

Decreased circulating IgA level

Decreased circulating IgE

Decreased circulating IgG level

Decreased circulating total IgM

Agammaglobulinemia

T lymphocytopenia

Impaired lymphocyte transformation with phytohemagglutinin

Hypoplasia of the thymus

Chronic oral candidiasis

Skin rash

Pneumonia

Recurrent pneumonia

Severe combined immunodeficiency

Recurrent fungal infections

Recurrent bacterial meningitis

Disease(s) Associated with IL2RG

X-linked severe combined immunodeficiency

Mouse Phenotypes

decreased T cell proliferation

cecum inflammation

absent uterine NK cells

small thymus cortex

thymus cortex hypoplasia

thymus hyperplasia

small thymus

thymus hypoplasia

decreased thymocyte number

abnormal thymocyte activation

enlarged spleen

spleen hyperplasia

abnormal class switch recombination

decreased immature B cell number

arrested B cell differentiation

decreased double-negative T cell number

decreased double-positive T cell number

abnormal gamma-delta T cell differentiation

abnormal myelopoiesis

increased neutrophil cell number

decreased myeloid dendritic cell number

abnormal B cell number

decreased mature B cell number

decreased plasma cell number

decreased pre-B cell number

decreased NK cell number

absent NK cells

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased NK T cell number

absent gamma-delta T cells

absent gamma-delta intraepithelial T cell

decreased regulatory T cell number

decreased T cell number

decreased single-positive T cell number

decreased lymphocyte cell number

increased macrophage cell number

increased monocyte cell number

abnormal leukocyte morphology

abnormal lymphocyte morphology

abnormal CD4-positive, alpha beta T cell morphology

abnormal alpha-beta intraepithelial T cell morphology

spleen hypoplasia

absent spleen germinal center

absent spleen white pulp

decreased spleen white pulp amount

abnormal splenic cell ratio

abnormal basophil physiology

abnormal mast cell physiology

abnormal immunoglobulin level

decreased IgE level

decreased IgG3 level

decreased IgG level

decreased IgM level

decreased immunoglobulin level

impaired natural killer cell mediated cytotoxicity

abnormal immune system cell morphology

abnormal immune system organ morphology

abnormal gut-associated lymphoid tissue morphology

enlarged Peyer's patches

absent Peyer's patches

abnormal mesenteric lymph node morphology

small lymph nodes

abnormal dendritic cell physiology

abnormal cell-mediated immunity

abnormal immune serum protein physiology

decreased interferon-gamma secretion

decreased interleukin-2 secretion

decreased interleukin-4 secretion

Availability

Mouse Genotype

Il2rg^tm1Cgn/Il2rg^tm1Cgn

Il2rg^tm1Krf/Il2rg^tm1Krf

Il2rg^tm1Sug/Il2rg^tm1Sug

Il2rg^tm1Wjl/Il2rg^tm1Wjl

Il2rg^tm1Cgn/Y

Il2rg^tm1Sug/Y

Il2rg^tm1Wjl/Y

Il2rg^tm1.1Asin/Il2rg^tm1Wjl
Tg(Cd4-cre)1Cwi/0 (conditional)

Il2rg^tm1.1Asin/Il2rg^tm1Wjl
Tg(Cd8a*-cre)B8Asin/0 (conditional)

Il2rg^tm2Cgn/Y
Tg(Mx1-cre)1Cgn/? (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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